OLR1 and infection: In contrast with the existing paradigm of LOX-1–driven injury and in support of antiinflammatory roles for LOX-1 as observed in the LOX-1–KO mice (Supplemental Figure 2), local blockade of this receptor exacerbated injury, as evidenced by elevated proteinaceous edema (total protein in the BALF) following infection with E. coli but not control (anti–LOX-1/saline) mice (Figure 2B).