To address whether LOX-1 content is dynamically regulated in response to respiratory infection, we induced left lobar pneumonias in adult C57BL/6 mice through intratracheal (i.t.)instillations of Escherichia coli (E. coli) and Streptococcus pneumoniae (serotype 3) (S. pneumoniae). The gene discussed is OLR1; the disease is respiratory tract infectious disorder.