Individual 1 was a 65-year-old male, carrying variants in MYBPC3 (c.3628-41_3628-17del, NM_000256.3) and TNNT2 (c.460C>T; p.Arg154Trp, NM_001276345.2) and was diagnosed with heart failure, with underlying chronic ischemic heart disease. Here, MYBPC3 is linked to heart failure.