TGFB3 and Arrhythmogenic right ventricular dysplasia: For example, many previous studies did not include all 8 curated genes with strong or moderate disease-gene association but also marked other genes (eg, TGFB3) with only limited evidence as associated with ARVC.14,15 In addition, we included both missense and loss of function variants, whereas prior studies only included loss of function variants.