TNNT2 and cardiomyopathy: This suggests that this variant is associated with heart failure in the setting of multiple forms of cardiomyopathy, and not simply HCM.26 Secondly, the c.862C>T p.Arg288Cys variant in TNNT2 was previously found in HCM individuals but is often observed in patients with a mild phenotype or in combination with other variants.