4-CBA (which inhibits the key enzyme COQ2 involved in CoQ biosynthesis) treatment successfully restored radiotherapy-induced lipid peroxidation and caused tumor suppression in KEAP1-mutant lung cancer cells [13], highlighting the translational application of 4-CBA treatment in radiotherapy to overcome radioresistance in KEAP1-inactivated lung tumors. This evidence concerns the gene KEAP1 and lung cancer.