Mechanistically, KEAP1 mutation-induced NRF2 stabilization initiates the transcription of antioxidant response element (ARE)-containing genes, including those involved in iron metabolism (like FTH1, FTL, HMOX1, etc.)or GSH metabolism (SLC7A11, GCLC, GCLM, GSS, TXNRD1, etc.), which contributes to cell survival and tumor development under increased oxidative or metabolic stress conditions [3, 4]. The gene discussed is KEAP1; the disease is neoplasm.