Perforin in this context has been postulatedto contribute to neuroinflammation, although its exact role in thepathology of these brain diseases is not yet fully understood.93 LAT1-utilizing prodrugs of perforin inhibitors(Figure 11) have improvedpermeation across the BBB and consequently increased brain exposureas demonstrated in pharmacokinetic studies (in contrast, the parentperforin inhibitors were not detected at all in the brain). Here, PRF1 is linked to brain disorder.