The ultrasound-associated differentially expressed genes and module hub gene intersection were selected for univariate Cox analysis to identify prognostic factors significantly associated with HCC, and finally, a 6-gene signature model consisting of SYNCRIP, B4GALT3, MCM6, CCT3, SNRPG, and HNRNPC was constructed to assess HCC patient prognosis. This evidence concerns the gene CCT3 and hepatocellular carcinoma.