For example, the frequency of TP53 gene mutations was significantly higher in the high-risk group in comparison with the low-risk group, and it has been demonstrated that in most TP53 mutant tumors, other tumor suppressor genes are similarly inactivated, and oncogenes that allow cancer progression are amplified (Donehower et al., 2019), resulting in poor prognosis, which is consistent with the worse prognosis of patients in our high-risk group. Here, TP53 is linked to cancer.