ALMS1 and Obesity: Breastfeeding impairment could be secondary to two mechanisms: (a) ALMS1 dysfunction could be directly correlated to milk production in glandular breast cells, and (b) as suggested in some observational studies, a PCOS-like phenotype associated to obesity could be a potential factor contributing to lower breastfeeding initiation and duration (Harrison et al., 2016; Author Anonymous, 1161).