This study showed that ALMS1 deficiency may promote anovulatory infertility via elevated androgens through a cooperation between ALMS1 and the luteinizing hormone (LH)/chorionic gonadotropin receptor, which induced a PCOS and obesity phenotype characterized by anovulation and hyperandrogenemia (Yu et al., 2021). Here, ALMS1 is linked to obesity due to melanocortin 4 receptor deficiency.