Although some studies demonstrated the prognostic value of the total number of lymph nodes examined (TNLE) and LNM in pNETs [19, 20], other research indicated that TNLE and LNM may have less important prognostic value in pNETs with some favorable characteristics (such as tumor ≤2 cm or Ki-67 index <3%) [21]. The gene discussed is MKI67; the disease is neoplasm.