Since this time, TDP-43 aggregation is now considered to be a general pathological marker for ALS and FTD (Saberi et al., 2015), as well as Alzheimer’s disease (Josephs et al., 2015), Parkinson’s disease (Nakashima-Yasuda et al., 2007), traumatic brain injuries (Johnson et al., 2011) and within the normal aging brain (Uchino et al., 2015). Here, TARDBP is linked to frontotemporal dementia.