Findings from ALS/FTD-FUS patient and disease models show that FUS regulates diverse cellular processes including those involved in synaptic transmission, signaling cascades, cytoskeleton dynamics mitochondrial function and energy metabolism (Schweitzer et al., 2006; Martins-De-Souza et al., 2012; Garone et al., 2020). Here, FUS is linked to amyotrophic lateral sclerosis.