Alterations in transcript and protein levels in TDP-43 models of ALS/FTD may involve several aspects of RNA metabolism including RNA trafficking, stability or translation regulation or possibly by its direct association with translation machinery (Russo et al., 2017; Chu et al., 2019; Charif et al., 2020; Sidibe et al., 2021). The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.