Changes in mitochondrial abundance have also been observed in ALS/FTD-FUS patients and other disease models (Tradewell et al., 2012; Deng et al., 2015; Tsai et al., 2020), which may occur due to aberrant interactions with mRNA or protein interactions that lead to global changes in protein synthesis (Nakaya and Maragkakis, 2018; Tsai et al., 2020; Salam et al., 2021). The gene discussed is FUS; the disease is frontotemporal dementia.