Indeed, mutations in several genes linked with proteostasis and autophagy including charged multivesicular body protein 2B (CHMP2B), sequestosome 1 (SQSTM1/p62), ubiquilin-2 (UBQLN2), and valosin containing protein (VCP) are linked with familial ALS and FTD (Liscic et al., 2020). Here, CHMP2B is linked to frontotemporal dementia.