C9orf72 and amyotrophic lateral sclerosis: Consistent with reports that C9ORF72 plays an important role in immune regulation (Burberry et al., 2016; O’Rourke et al., 2016; Sudria-Lopez et al., 2016), proteins associated with astrocytes and microglia were slightly enriched in ALS-C9 when compared to sporadic ALS (Umoh et al., 2018).