One study examined mRNA stability in ALS-C9 fibroblasts and iPSCs and found that destabilization of ribosomal (RPL28, RPL38, RPS18) and mitochondrial transcripts (COX6B, COX6C-X1, COX5B, NDUFA1, NDUFA13) occurs, consistent with ALS/FTLD-C9 and sporadic ALS brain and spinal cord tissues (Tank et al., 2018). This evidence concerns the gene COX6B1 and amyotrophic lateral sclerosis.