MAPT and Alzheimer disease: Alzheimer’s disease (AD) is a neurodegenerative disease characterized by progressive memory loss and cognitive impairment with the deposition of β-amyloid protein (Aβ) in β-amyloid plaques (APs) and hyperphosphorylated tau in neurofibrillary tangles (NFTs) (Laferla and Oddo, 2005).