Indeed, secretome studies on AF-MSC indicated the presence of anti-inflammatory molecules such as interleukins IL-10, IL-1ra, IL-13, and IL-27; and angiogenic factors like angiopoietin-1, PD-ECGF, uPA that can contribute to the functional improvement of DSS-induced colitis in immunodeficient colitis mouse model phenotype (Legaki et al., 2016). This evidence concerns the gene ANGPT1 and colitis.