ERβ overexpression in several human CRC cell lines also suppressed proliferation and induced apoptosis by increasing p21 and p27 cell cycle inhibitors, and Casp-3 and Cyto-C pro-apoptotic proteins, whilst reducing BCL2 and survivin anti-apoptotic proteins (18, 20–23). The gene discussed is BIRC5; the disease is colorectal carcinoma.