By univariate linear regression analysis in Table 2, we found significant correlations between urinary IL-18 and age (r = 0.224, p = 0.002), male sex (r = −0.253, p = 0.001), duration of T2D (r = 0.259, p < 0.001), SBP (r = 0.228, p = 0.002), hemoglobin (r = −0.239, p = 0.002), albumin (r = −0.305, p < 0.001), eGFR (r = −0.237, p < 0.001), UACR ≥ 30 mg/g (r = 0.224, p = 0.003), and serum IL-18 (r = 0.219, p = 0.004) in participants with T2D. Here, IL18 is linked to type 2 diabetes mellitus.