The strength of the present study is that it not only seeks to explore the association of the rs7903146 polymorphic form of TCF7L2 gene with altered postprandial triglycerides metabolism but also examines for the first time whether altered adipocyte expression of this gene could also be associated with significant postprandial hypertriglyceridemia and insulin resistance. Here, TCF7L2 is linked to Insulin resistance.