Of note, the AUC of PIVKA-II alone to -HCC was 0.859 (0.819-0.893), which was better than the performance of AFP alone (0.804 [0.759-0.843]; P = 0.084) or AFP-L3% alone (0.727 [0.678-0.773], P <0.001. The gene discussed is AFP; the disease is hepatocellular carcinoma.