NOTCH1 and cancer: However, the overexpression of lncRNA NIFK-AS1 can suppress cancer growth by sponging miR-146a and upregulating Notch1, thus inhibiting estrogen-induced proliferation, migration, and invasion of endometrial cancer cells (53).In addition, the expression of lncRNA cox-2 is higher in M1 type than in M2 type macrophages.