In epithelial ovarian cancer (EOC), a stimulant, phorbol 12-myristate 13-acetate, induces M2-like TAMs and triggers the secretion of epidermal growth factor (EGF), which promotes proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) of EOC cells via activation of the EGFR-ERK signaling pathway. This evidence concerns the gene EGF and ovarian carcinoma.