NCOA3 and Noncompaction cardiomyopathy: It has been reported that SRC-3 has an ER-dependent vasoprotective role in vascular trauma by suppressing vascular cell proliferation 13, and deletion of SRC-1/3 causes noncompaction cardiomyopathy in the hearts of newborn and adult mice by inhibiting cardiomyocyte proliferation and differentiation 14, suggesting that SRC-3 has a protective role in cardiovascular; however, the biological role of SRC-3 in atherosclerosis remains poorly defined.