We found that mice on the ApoE-/- background that were infected with endothelial-specific AAV9-shSRC-3 also exhibited significant reductions in atherosclerotic plaques, similar to the effects of global SRC-3 deficiency on the ApoE-/- background, suggesting that endothelial SRC-3 contributes to atherosclerosis development. Here, APOE is linked to atherosclerosis.