NCOA3 and colitis: Our recent study demonstrated that SRC-3-/- mice displayed delayed clearance of Citobacter rodentium and more severe tissue pathology after oral infection with C. rodentium due to decreased production of the chemokines CXCL2 and CXCL5 and decreased recruitment of neutrophils, indicating that SRC-3 plays a critical protective role in bacteria-induced colitis 12.