Given the quantity of immune cell infiltration could not comprehensively reveal the LGALS9's influence on primary immunodeficiency and the quantity alteration in exhausted T cells, cytotoxic T cell representing the ability of immune activity, for the sake of further understanding the immune cells quality alteration based on Gal-9 expression, we performed GSEA in GSE30219 dataset focusing on biological process. This evidence concerns the gene LGALS9 and inborn error of immunity.