Figure S4 demonstrated that the top 15 high Gal-9 expression-related biological process with enrichment scores > 0.85 and adjusted P < 0.01, and some interesting processes were as follows: “negative regulation of myeloid leukocyte mediated immunity”, “positive regulation of tolerance induction”, “negative regulation of cell killing”, “negative regulation of natural killer cell mediated immunity”, “negative regulation of natural killer cell mediated cytotoxicity”, which indicated the LGALS9's influence on primary immunodeficiency with worse or failure of immune activity. The gene discussed is LGALS9; the disease is inborn error of immunity.