In summary, in current studies, for the first time, we elucidated the function of hsa_circ_0003823 in ESCC and the underlying mechanism by regulating the expression of CRISP3 through sponge adsorption of miR-607, thereby promoting the progression, metastasis and Apatinib resistance of ESCC. This evidence concerns the gene CRISP3 and esophageal squamous cell carcinoma.