CRISP3 is a member of the cysteine-rich secretory proteins, and it has been reported that CRISP3 was involved in the occurrence, development and drug resistance in a variety of tumors including prostate cancer, non-small cell lung cancer, breast cancer and so on 31-34, however, its role in ESCC remained unknown. Here, CRISP3 is linked to esophageal squamous cell carcinoma.