To verify whether the JNK and P38 pathways promote apoptosis in HCC cells, we divided Huh-7 and HCCLM3 cells into the following 4 groups: vector: NTF3-overexpressing negative control group; NTF3: NTF3-overexpressing group; NTF3+SP600125, and NTF3+SB20358. Here, MAPK8 is linked to hepatocellular carcinoma.