Taken together, these data, along with the above in vitro and in vivo results, demonstrate that platelet-secreted EVs from NPC patients can be absorbed by NPC cells and induce increased ITGB3 and SLC7A11 expression to inhibit ferroptosis, and thereby accelerating distant metastasis and the formation of metastatic foci of NPC cells through the MET process. Here, ITGB3 is linked to nasopharyngeal carcinoma.