ITGB3 and nasopharyngeal carcinoma: More importantly, using a parallel plate flow adhesion assay, we demonstrated that P-EVs increased the adhesion of NPC cells under conditions of 5 dynes/cm2 shear forces, but this adhesion was abolished by cilengitide (Figure 2J), suggesting that P-EVs may promote the adhesion of blood-circulating NPC cells to mediate the formation of secondary metastatic foci by inducing ITGB3 expression.