Remarkably, although RSL3 treatment suppressed the migration and invasion of 6-10B and 5-8F cells, P-EVs treatment and ITGB3 overexpression still facilitated the migration and invasion of 6-10B and 5-8F cells in the presence of RSL3 (Figure S5F and Figure 5F), suggesting that P-EVs-upregulated ITGB3 expression promoted the metastasis of NPC cells through SLC7A11-suppressed ferroptosis. Here, SLC7A11 is linked to nasopharyngeal carcinoma.