To investigate the potential mechanisms underlying P-EVs-upregulated ITGB3 expression promoting NPC cell metastasis and antagonizing ferroptosis, we detected the expression of SLC7A11, a subunit unique to the xc(-) system, which modulates ferroptosis and tumor metastasis by maintaining the intracellular redox balance of cancer cells 31. This evidence concerns the gene ITGB3 and neoplasm.