Using BODIPYTM 581/591 C11 as a lipid peroxidation probe, we demonstrated that although ITGB3 knockout and RSL3 treatment increased lipid peroxidation, which is a hallmark of ferroptosis, P-EVs treatment and ITGB3 overexpression inhibited RSL3-induced lipid peroxidation in NPC cells (Figure 3E and Figure S3B). The gene discussed is ITGB3; the disease is nasopharyngeal carcinoma.