Further analysis by ELISA revealed that ITGB3 expression level was significantly higher in platelet-rich plasma- and platelet-derived EVs from NPC patients than in those from healthy volunteers, and the expression level of ITGB3 in platelet-derived EVs is positively correlated with the distant metastasis of NPC patients (Figure 1A). This evidence concerns the gene ITGB3 and nasopharyngeal carcinoma.