ITGB3 and nasopharyngeal carcinoma: In the current study, we found that P-EVs treatment led to a decrease in intracellular ROS, lipid-ROS, mitochondrial damage, intracellular iron (Fe2+) and an increase in the GSH/GSSG ratio, that is, suppressed ferroptosis, by upregulating ITGB3 and therefore enhancing the distant metastasis of NPC cells (Figure 3 and Figure 5).