Considering that integrins are the major receptor family in platelets and have been associated with cancer progression and metastasis 26, 27, we further explored the interrelationship between P-EVs-induced ITGB3 upregulation and NPC progression and metastasis by constructing ITGB3-overexpressing and knockout 6-10B and 5-8F cells (Figure S2C). Here, ITGB3 is linked to cancer.