Conversely, the GSH/GSSG ratio, a cellular antioxidant system that prevents oxidative damage, was elevated by P-EVs treatment and ITGB3 overexpression (Figure 3B), suggesting that P-EVs-upregulated ITGB3 expression likely inhibits oxidative stress and therefore antagonizes ferroptosis in NPC cells. Here, ITGB3 is linked to nasopharyngeal carcinoma.