As mentioned, adipose tissue is not only a source of autocrine FGF21 but also a direct and predominant target of hepatic FGF21, which may result in a substantial enrichment of FGF21 in the microenvironment of the tumors growing in the anatomical vicinity of adipose tissue, such as breast, renal and colon cancers. The gene discussed is FGF21; the disease is malignant colon neoplasm.