A recent study found that methionine adenosyltransferase Matla knockdown prevented and reversed obesity, insulin resistance, and hepatosteatosis via stimulating the expression and secretion of hepatic FGF21, which subsequently activated the liver-adipose tissue axis resulting in increased BAT thermogenesis, WAT lipolysis, and secretion of adiponectin 65. The gene discussed is FGF21; the disease is Insulin resistance.