NF-E2-related factor 2 (NRF2)-Kelch-like ECH-associated protein 1 (KEAP1) pathway and endoplasmic reticulum (ER) stress are the two important factors in the primary adipocytes causing the risk of obesity (Wang et al., 2016); while curcumin and its metabolites are the signaling modulators to improve the lipolysis and insulin resistance for preventing obesity (Ye et al., 2017). This evidence concerns the gene NFE2L2 and obesity due to melanocortin 4 receptor deficiency.