IRS1 and Obesity: As the phosphorylation of an insulin receptor substrate 1 (IRS-1)/phosphoinositide 3-kinase (PI3K)/Akt and downstream signaling pathways, forkhead box protein O1 (FOXO1), and glycogen synthase kinase 3β (GSK3β) are modulated by THC to decrease the risk of obesity (Chen et al., 2018).