It is a novel therapeutic use for type 2 diabetes since it is improving insulin signaling, glucose utilization, and lipid metabolism through the AdipoR1/R2-APPL1-mediated pathway, which upregulated via the uncoupling protein 1 (UCP-1) in adipose tissue and elevated adiponectin levels in the circulation of liver and skeletal muscle (Tsai et al., 2021). The gene discussed is UCP1; the disease is type 2 diabetes mellitus.