As the phosphorylation of an insulin receptor substrate 1 (IRS-1)/phosphoinositide 3-kinase (PI3K)/Akt and downstream signaling pathways, forkhead box protein O1 (FOXO1), and glycogen synthase kinase 3β (GSK3β) are modulated by THC to decrease the risk of obesity (Chen et al., 2018). The gene discussed is IRS1; the disease is obesity due to melanocortin 4 receptor deficiency.