Berberine-containing medicinal plants have been applied in TCM to treat parasitic intestinal infection, bacterial diarrhea, and diabetes for a long time through the suppression of fatty acid synthase, acyl-CoA synthase, acetyl-CoA carboxylase, SREBP-1, C/EBPα, and PPARγ (Choi et al., 2006; Hu and Davies, 2009). Here, SREBF1 is linked to diabetes mellitus.