(A) Triptolide is an inflammatory mediator that inhibits the activation of the AMPK/mTOR signaling pathway to reduce the secretion of chemokine, monocyte chemotactic protein-1 (MCP-1) in Kupffer cells (KCs), Ma-CM, or 3T3-L1 to ameliorate obesity-induced inflammatory diseases (Li and Liu, 2021). This evidence concerns the gene CCL2 and obesity due to melanocortin 4 receptor deficiency.