Amiloride can prevent the neuronal proton-gated acid-sensing ion channel 1 (ASIC1), which is overexpressed in axons and oligodendrocytes in MS lesions, from having its neuroprotective and myeloprotective effects. A further benefit of amiloride’s preventive action occurring later in the course of inflammation is that it makes it active even before inflammation begins. The gene discussed is ASIC1; the disease is myeloid sarcoma.