Chronic adverse stress, which can increase brain angiotensin II levels, is one of the main environmental factors of AD. Because it has been shown that angiotensin II increases are linked to amyloidogenesis, using angiotensin receptor blockers may be useful in delaying the loss of cognitive processing. Additionally, valsartan reduces inflammation, vasoconstriction, and mitochondrial dysfunction while encouraging acetylcholine release. Here, AGT is linked to Alzheimer disease.