The pooled results showed that TGP combined with H1-antihistamine was superior to H1-antihistamine alone in the cure rate (risk ratio (RR) = 1.54, 95% confidence interval (CI) = 1.39 to 1.71, <i>p</i> < 0.00001), total efficacy rate (RR = 1.33, 95%CI = 1.26 to 1.40, <i>p</i> < 0.00001), urticaria activity score 7 (mean difference (MD) = -4.03, 95%CI = -6.62 to -1.44, <i>p</i> = 0.002), recurrence rate (RR = 0.31, 95%CI = 0.20 to 0.46, <i>p</i> < 0.00001), and the level of IgE in serum (standardized mean difference (SMD) = -1.96, 95%CI = -3.02 to -0.90, <i>p</i> = 0.0003). This evidence concerns the gene IGHE and urticaria.