Variously, sclareol-loaded lipid nanoparticles effectively improved metabolism and attenuated obesity process in obesity induced mice, which was attributed to the decreased expression of proinflammatory cytokines (NF-kB and MCP-1) and adipogenesis related markers SREBP-1 (Cerri et al., 2019). This evidence concerns the gene NFKB1 and obesity due to melanocortin 4 receptor deficiency.