ITGAM and autoimmune disease: With the aim of ameliorating autoimmune disorders related to local and systemic immunities, we studied the changes in the immune cells in the local prostate and systemic environments of mice with EAP, especially the changes in the CD11b+ mononuclear cell/macrophage populations, which are of great significance for the study of prostate inflammation and pelvic pain (Roca et al., 2009).