Due to the ability of GABA-B receptor agonists and GABA-B receptor allosteric modulators to downregulate the neuronal stress circuit, these medications have been investigated for therapeutic use in stress-related psychiatric disorders including anxiety, mood-disturbances and alcohol use disorder (Morley et al., 2014; Felice et al., 2022). The gene discussed is GABBR1; the disease is alcohol abuse.