Moreover, in breast cancer cells, ω-3 polyunsaturated fatty acids such as DHA and EPA induce the degradation of EZH2 by the proteasome pathway, thereby downregulating EZH2 protein levels and alleviating the transcriptional repression of EZH2 target genes such as E-cadherin and IGFBP3(Dimri et al., 2010). Here, EZH2 is linked to breast cancer.