In pediatric high-grade gliomas, specifically diffuse midline gliomas (DMG) which is characterized by the signature K27M mutation in histone H3, EZH2 ablation promotes tumor cell proliferation, while EZH2 overexpression reverses this effect in H3WT DMG mouse models (Dhar et al., 2022). The gene discussed is EZH2; the disease is diffuse midline glioma.