MAD2L2 and ovarian cancer: In ovarian cancer cell lines with high CARM1 expression, EZH2 levels are upregulated, allowing activation of homologous recombination repair by exerting transcriptional repression on nonhomologous recombination repair-related genes, such as MAD2L2 (mitotic arrest deficient 2 like 2, MAD2L2) (Karakashev et al., 2020).