While it has been reported that in patients with MIS-C the Th1 pathway [i.e., IFN-γ-related (21)] is enhanced and the Th2 responses are suppressed (19), we found a reduced number of activated Th1 cells which, in most MIS-C patients were almost absent (although such reduction was transient, see below). Here, IFNG is linked to COVID-19–associated multisystem inflammatory syndrome in children.