CEP55 and hepatocellular carcinoma: Figure 1A shows the locations of CNV alterations of 11 MARCH ligase genes on chromosomes. In contrast, MARCH 1, MARCH 2, MARCH 3, MARCH 5, MARCH 7, and MARCH 8 had prevalent CNV deletions (Figure 1B). Further analysis demonstrated that MARCH 2–11 were significantly upregulated in HCC samples (Figure 1C, Figure Supplement 2).