We established a prognostic signature (risk score) to evaluate and quantify HCC individuals, including eight MARCH ligase-related genes (CYP2C9, G6PD, SLC1A5, SPP1, ANXA10, CDC20, PON1, and FTCD) in the TCGA-HCC cohort. This evidence concerns the gene SLC1A5 and hepatocellular carcinoma.