NFKB1 and infection: In the specific case of infection with SARS-CoV-2, as the cholinergic anti-inflammatory mechanism controls NF-κB action through Acetylcholine coupled to the α7n-Acetylcholin-receptor (11), insufficient vagal activity appears to be the cause of both unhindered viral replication and uncontrolled cytokine release along the virus-driven NF-κB pathway (12).