However, another study found that genetic deficiency of the atypical chemokine receptor 2 (Ackr2-/-) in Apcmin/+ mice led to reduced tumour burden, which the authors attributed to an increase in mast cells that can recruit CD8+ T cells through leukotriene B4 (LTB4) (129). The gene discussed is ACKR2; the disease is neoplasm.