In CAC, the pro-tumoral role of Tregs has been attributed to thymic stromal lymphopoietin (TSLP) rather than IL-33 in one study, as Treg-specific deletion of the TSLP receptor (TSLPR) (Foxp3IRES-creTslprf/f) but not ST2 (Foxp3IRES-creIl1rl1f/f) reduced AOM/DSS-mediated CAC (143). Here, IL33 is linked to infectious otitis media.