Whether IL-25 and IL-33-mediated eosinophilia occurs in other subtypes of CRC inhibiting tumorigenesis remains to be established, however unlike CAC, most studies are concordant with IL-25 and IL-33 promoting tumorigenesis in APC-mutation-mediated CRC (81, 84, 91). The gene discussed is IL25; the disease is Increased total eosinophil count.