Conversely, others have found that decreased IL33 and ST2 expression is associated with advanced human CRC and poor survival respectively, and ST2+ CRC showed reduced vascular invasion and lymph node metastasis (89, 90), indicating that the role of IL-33 and ST2 in CRC is likely complex and may depend on the CRC subtype and disease stage. This evidence concerns the gene IL1RL1 and colorectal carcinoma.