HPGDS and infectious otitis media: In an AOM/DSS model of CAC, deficiency in hematopoietic prostaglandin D synthase (H-PGDS) exacerbated tumorigenesis, and adoptive transfer of mast cells deficient in H-PGDS, but not wild type mast cells, into mast cell-deficient (Kitw-sh/w-sh) mice exacerbated tumorigenesis (130).