Similar to the homeostatic intestine and mirroring IL-25 expression during parasitic infection (30), DCLK1+ tuft cells were found to be the main source of IL-25 in tumours in mouse models of APC-mutation-mediated CRC (Apc1322T/+) (81) and azoxymethane (AOM)/dextran sodium sulphate (DSS)-mediated model of colitis associated cancer (CAC) (80), indicating that IL-25 expression by tuft cells is conserved across different subtypes of CRC. Here, IL25 is linked to parasitic infectious disease.