Because it has been widely reported that chronic inflammation (as in erosive OLP) can lead to ES and several cases of ES have been described in autoimmune blistering diseases (e.g. PV and bullous pemphigoid), it is reasonable that humoral ES can lead to the production of IgG autoantibodies against Dsg1 and 3 in patients affected by erosive OLP (19). This evidence concerns the gene DSG1 and inflammation.