As PHOX2B, MYC/MYCN and other developmentally regulated transcription factors are key components of the CRC that supports the rapidly proliferating progenitor phenotype of neuroblastoma cells, and as ASCL1 KO cells divide more slowly than parental cells, we investigated whether ASCL1 deletion was downregulating expression of CRC components including MYC/MYCN that are known to support proliferation and oncogenicity (Durbin et al., 2018). The gene discussed is PHOX2B; the disease is colorectal carcinoma.