However, ASCL1 does promote binding of the CRC factors Paired-like homeobox 2b (PHOX2B), GATA binding protein 3 (GATA3) and MYC/MYCN to chromatin; a reduction in this binding is likely to lead to the reduced cell growth seen when ASCL1 is deleted. The gene discussed is ASCL1; the disease is colorectal carcinoma.