The adrenergic identity of the ADRN subtype of neuroblastoma cells is maintained by a transcriptional core regulatory circuit (CRC) of predominantly developmental regulators of neurogenesis including PHOX2B, GATA3 and ASCL1, whose expression is further maintained by high levels of MYC or MYCN (Boeva et al., 2017; van Groningen et al., 2017; Wang et al., 2019). The gene discussed is ASCL1; the disease is neuroblastoma.