ASCL1 and neuroblastoma: ASCL1 and other developmental regulators of neurogenesis form an aberrant ‘core regulatory circuit’ (CRC), that promotes oncogenicity of neuroblastoma cells (Boeva et al., 2017; van Groningen et al., 2017; Wang et al., 2019), where mutually regulated high levels of expression of the circuit genes is usually reinforced by elevated MYCN (Wang et al., 2019).