As ASCL1 KO cells grow more slowly than parental lines and growth is reported to be supported by this CRC network, Wang et al. had suggested that knock-down of ASCL1 in Kelly cells led to suppression of GATA3 and PHOX2B transcription, which might have explained this slower growth (Wang et al., 2019). This evidence concerns the gene PHOX2B and colorectal carcinoma.