MYCN and neuroblastoma: As well as developmental regulators of neurogenesis, the MYC or MYCN oncogenes play a key role in maintaining the high level of cell growth in neuroblastoma tumours; the proliferation of SH-SY5Y cells is supported by MYC and the proliferation of IMR32 is driven by MYCN (Vandesompele et al., 2003; Zimmerman et al., 2018).