Wang et al saw that downregulation of ASCL1 using siRNA from its usual very high level in Kelly neuroblastoma cells to a more modest level, resulted in a decrease in the expression of PHOX2B and GATA3 (Wang et al., 2019), supporting a role for ASCL1 in maintenance of the CRC. The gene discussed is PHOX2B; the disease is colorectal carcinoma.