It is well known that glucocorticoids inhibit the survival of osteoblasts and promote the life span of osteoclasts through glucocorticoid receptors, leading to the risk of bone loss (Güler-Yüksel et al., 2018; Lee et al., 2021).One study found that the expression of lncRNA GAS5 in B cells of RA patients was obviously decreased. Here, NR3C1 is linked to rheumatoid arthritis.