PRDM16 and neoplasm: Our results demonstrated that PRDM16 functioned as a tumor suppressor gene, and this may be explained in Fei et al.‘s study, which showed that PRDM16 could regulate histone methylation in the promoter region of MUC4 to reduce its expression and inhibit the EMT process mediated by MUC4 (Fei et al., 2019).