Since WTAP interacts with METTL3 and METTL14 and is required for their localization into nuclear speckles enriched with pre-mRNA processing factors and for the catalytic activity of m6A methyltransferase in vivo (Ping et al., 2014), it presented the fact that the WTAP+ fibroblasts regulates the pre-mRNA processing and promotes the m6A methyltransferase activity during the formation of keloid. The gene discussed is WTAP; the disease is keloid.