Above all, in order to further optimize and improve the clinical detection mode, 115 DLBCL patients and 65 healthy subjects are selected for detection and analysis in this study, and the correlation between serum bFGF and IPI score is observed, in order to further explore the mechanism of serum bFGF influencing the disease development and prognosis. The gene discussed is FGF2; the disease is diffuse large B-cell lymphoma.