For a long time, the clinical guidelines for the timing of termination of pregnancy for pregnant women with GDM refer to the traditional diagnostic criteria of GDM: for GDM patients treated with insulin, it is recommended to control blood glucose until 38∼39 weeks and then terminate the pregnancy; for GDM patients free from insulin therapy, it is recommended to observe until 40 weeks then terminate pregnancy. The gene discussed is INS; the disease is gestational diabetes.