IL18 and central nervous system infectious disorder: High levels of IL-1β and IL-18 are present in the cerebrospinal fluid, brain tissue, and plasma of patients with central nervous system infection, brain injury, AD, and multiple sclerosis, and increased NLRP3 protein expression is associated with high IL-1β It was correlated with the serum level of IL-18, indicating that NLRP3 inflammasome activation is involved in the pathological process of neurological diseases (Karpenko et al., 2018; Irrera et al., 2020; O’Brien et al., 2020).