Among the six genes, differential expression levels on the part of AKT3, IRF9, RORA, and TNFRSF12A were observed between the healthy group and the IPF group (p < .05; Figure 3(d)); this result was also supported by the SMOTE data (p < .05; Figure S2). The gene discussed is TNFRSF12A; the disease is idiopathic pulmonary fibrosis.