CCND1 and Familial prostate cancer: For example, Wang et al. [37] showed that cyclin D1 and cyclin E1 are specific targets of miR-16-5p and that miR-16-5p overexpression can downregulate expression of cyclin D1 and cyclin E1 and induce cell cycle arrest in G0/G1 phase, which enhances radiosensitivity of prostate cancer cells.