Moreover, TRIM59, a member of the TRIM protein family that is associated with autophagy, immunity, anti-virus, and carcinogenesis and plays roles in the pathogenesis of osteoarthritis, sepsis, and myocardial ischemia-reperfusion injury [21–25], and TRIM59 overexpression can facilitate the invasion of ectopic ESCs (Ect-ESCs) [26]. The gene discussed is TRIM59; the disease is osteoarthritis.