CCK promotes the proliferation and survival of tumor cells, and thus the blockade of the CCK receptor with its antagonists suppresses the proliferation and induces the apoptosis of tumor cells, leading to the inhibition of tumor growth in vivo (Morimoto et al., 1993; Ponnusamy et al., 2016; Smith et al., 2016). The gene discussed is CCK; the disease is neoplasm.