Their research discovered that NOD1 overexpression in the TriDAP-induced estrogen-sensitive cell line MCF-7 can inhibit tumor development, but NOD1 deficiency in MCF-7 cells accelerates tumor growth and increases estrogen-dependent tumor cell proliferation due to an inability to process NOD1-mediated TNFα-induced apoptosis with IL-8 upregulation. This evidence concerns the gene CXCL8 and neoplasm.