Thirty-six pyroptosis genes exhibited significantly higher transcriptional levels in HCC, including APIP, BAK1, BAX, CASP3, CASP4, CASP6, CASP8, CASP9, CHMP2A, CHMP2B, CHMP3, CHMP4A, CHMP4B, CHMP4C, CHMP6, CHMP7, CYCS, DFNA5, DHX9, GPX4, GSDMB, GSDMC, GSDMD, HMGB1, IL1A, IRF2, NLBP1, NLRP9, NOD1, NOD2, PLCG1, PRKACA, PYCARD, SCAF11, TIRAP, and TP53. Here, GSDMB is linked to hepatocellular carcinoma.