Thirty-six pyroptosis genes exhibited significantly higher transcriptional levels in HCC, including APIP, BAK1, BAX, CASP3, CASP4, CASP6, CASP8, CASP9, CHMP2A, CHMP2B, CHMP3, CHMP4A, CHMP4B, CHMP4C, CHMP6, CHMP7, CYCS, DFNA5, DHX9, GPX4, GSDMB, GSDMC, GSDMD, HMGB1, IL1A, IRF2, NLBP1, NLRP9, NOD1, NOD2, PLCG1, PRKACA, PYCARD, SCAF11, TIRAP, and TP53. Here, CHMP3 is linked to hepatocellular carcinoma.