PTGDS and neurodegenerative disease: In all neurodegenerative diseases, cell death is the final outcome but is often preceded by clinical neurological deficits.33,34 L-PGDS, is a multifunctional protein that inhibits astrocyte proliferation and astrocyte mitochondrial ATP production.35 As astrocytes play an important role in the integrity of neurones, a high L-PGDS concentration could have a harmful effect on ON axons.