This result was not so surprising since several reports previously showed that TLR2 deficient mice are significantly more susceptible to S. aureus-induced infections and display increased bacterial loads in different organs in comparison to their wild-type counterparts (Takeuchi et al., 2000; Miller et al., 2006; Sun et al., 2006; Stenzel et al., 2008; Schmaler et al., 2009). This evidence concerns the gene TLR2 and infection.