In addition, dapagliflozin, an SGLT2 inhibitor, partially reversed the downregulation of PGC-1α expression brought on by hyperglycemia in HK-2 cells, in mouse primary renal proximal tubule cells, and in the renal cortex of hyperglycemic mice fed a high-fat diet [49]. This evidence concerns the gene PPARGC1A and Hyperglycemia.