The low PGC-1α levels were also significantly increased by the SGLT2 inhibitors empagliflozin and canagliflozin in the cardiomyocytes and adipocytes of high-fat diet/streptozotocin-induced diabetic mice and rats [50–53], which was consistent with the effect of SGLT2 inhibitors to reverse hyperglycemia-induced downregulation of PGC-1α expression in the kidney. Here, PPARGC1A is linked to Hyperglycemia.