PPARGC1A and glomerulosclerosis: On the other hand, PGC-1α overexpression or maintenance of PGC-1α expression and activity by its activators (resveratrol, PGRN, berberine, Rap1, Tug1, and pyruvate kinase M2) ameliorated renal function deterioration and glomerulosclerosis and decreased mitochondrial ROS generation in tubular and mesangial cells as well as podocytes in vitro and in vivo [23, 29, 34–40].