(Tsigaridas et al., 2018; Weaver et al., 2018) Previous studies identified 8 differently expressed proteins (IGKC, LAC3, APOE, CLUS, TRFE, APOH, XIV and COEA1) between IBS patients (n = 30) and healthy individuals (n = 10). Here, IGKC is linked to irritable bowel syndrome.