In stage I, we identified 47 IBS-associated candidate autoantigens including 8 significant candidate autoantigens IgG, 2 IgA between IBS and HCs; 13 significant candidate autoantigens IgG, 13 IgA between IBS and DCs; 9 IgG and 2 IgA candidate autoantigens between IBS subgroups. The gene discussed is CD79A; the disease is irritable bowel syndrome.