(Törnblom et al., 2007; Fan et al., 2018; Morales et al., 2019) In 2012, Wood et al. found 3 antigens out of an 8,000 immunoproteinarray in the sera of 3 cases of IBS patients, including a nondescript ribonucleoprotein (RNP-complex), a small nuclear ribonuclear polypeptide A, and a Ro-5200 kDa. This evidence concerns the gene RNPC3 and irritable bowel syndrome.