To date, there are several antibodies reported in IBS, including antibodies against GnRH, flagellin, food allergens (IgE type), voltage-gated calcium channels (VGCCs), antibodies to cytolethal distending toxin B (anti-CdtB), anti-vinculin, anti-gliadin IgA, anti-enteric neuronal antibodies, antihuman tissue transglutaminase (h-tTG IgA) and deamidated gliadin peptide antibodies (DGP II IgA and DGP II IgG) and anti-alpha3-AChR antibodies. The gene discussed is VCL; the disease is irritable bowel syndrome.