Overall, the positive rate of containing any IgG autoantibody among the 14 IgG autoantibodies is significantly higher in IBS than HCs (46.7% vs. 27.5%, p < 0.001), the positive rate of containing any IgA autoantibody among the 14 IgA autoantibodies is significantly higher in IBS than HCs (55.7% vs. 32.8%, p < 0.0001), and the positive rate of containing any IgG/IgA autoantibody is significantly higher in IBS than HCs (69.0% vs. 42.7%, p = 0.019). Here, CD79A is linked to irritable bowel syndrome.