Concerning IBS compared to IBD, IBS-D subjects had higher titers of plasma anti-CdtB (1.49 ± 0.56 vs. 1.04 ± 0.33, p < 0.0001) and anti-vinculin (1.66 ± 0.97 vs. 0.88 ± 0.65, p = 0.0006) than IBD subjects by ELISA. Here, VCL is linked to inflammatory bowel disease.