Anti-PIGP IgA and anti-TCEAL6 IgA positive IBS patients had more days of defecated-associated abdominal pain/discomfort per month than negative patients (23.0 ± 8.0 vs. 20.0 ± 8.0, p = 0.041; 25.0 ± 6.0 vs. 21.0 ± 8.0, p = 0.037). Here, PIGP is linked to irritable bowel syndrome.